Entering the fifth paradigm for chemistry!—this is the title of the first ChemAI Day, organised this November 16th on our Science Park Campus in Amsterdam. Of course, AI4SMM will be present at this event to discuss with anyone interested the ChemAI question: how AI is changing chemical discovery? And our take on this qustion is, not surprisingly, how can AI help to do this in a sustainable manner? Please join us! We are looking forward to connect with academic and industrial partners to enlarge our consortium.